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A clinical trial was undertaken to clarify the efficacy and safety of the combination of uracil/tegafur and mitomycin C in patients with colon and rectal cancer. Thirty-one patients were included in this study. The clinical efficacy of this combination was compared with that of mFOLFOX6. The response rate was 44.8%, and the disease control rate was 77.4%. Side-effects were generally mild. The results suggest that the combination of uracil/tegafur and mitomycin C is effective as a first-line therapy for patients with metastatic or unresectable colon or rectal cancer. 0b46394aab